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KMID : 0861120110150010001
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Korean Journal of Oriental Preventive Medicine
2011 Volume.15 No. 1 p.1 ~ p.16
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Proposed Mechanisms and Further study for Korean Traditional medicines-Drug Interaction in a view of Toxicology
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Park Yeong-Chul
Kim Myoung-Dong
Lee Sun-Dong
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Abstract
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Objectives: The mechanisms for korean traditional medicine-drug interaction has not been well reviewed in spite that the chance for co-administration with western drugs or diet supplements has been increased. Especially, it is well known that various cytochrome P450s play a major role in drug-drug interaction. Of course, Korean traditional medicines is not excluded in a view of metabolism or biotransformation by cytochrome P450. This article was focused on reviewing the possible roles of cytochrome P450 in Korean traditional medicine-drug interaction, Also, the directions for further studies were suggested in terms of Korean traditional medicine-drug interaction.
Methods: New studies for korean traditional medicine-drug interaction were reviewed and summarized in terms of cytochrome P450 activities by various Korean traditional medicines and western drugs.
Results and Conslusions: Even if a few studies related to Korean traditional medicine-drug interactions was carried out, almost no studies for Korean traditional medicine-drug interactions has been found in a view of cytochrome P450. It was suggested that Korean traditional medicines and their decoction should be analyzed that how they effects on cytochrome P450, expecially CYP 1, 2, 3 families and how they interact with western drugs.
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KEYWORD
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Korean traditional medicine, drug-drug interaction, cytochrome P450, toxicity
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